Pseudoepitheliomatous hyperplasia (PEH) is a reactive epithelial proliferation secondary to a wide range of stimuli, including traumatic injury, inflammation, infection, and tumors of the skins. PEH secondary to burn injury is rarely reported. We report 3 cases of PEH patients after burn injury. All three cases were confirmed with the existence of bacterial infection, and all these cases were second or third degree burns. All 3 patients were treated with negative pressure wound therapy after wound debridement or tangential excision. All the wounds healed without split-thickness skin grafting and recurrence.